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Description
IκBα Recombinant Rabbit mAb (SDT-457-9)Product Specification Host Rabbit Antigen IB Synonyms NF kappa B inhibitor alpha; I kappa B alpha; IkB alpha; IkappaBalpha; Major histocompatibility complex enhancer binding protein MAD3; NFKBIA Location Cytoplasm, Nucleus Accession P25963 Clone Number SDT 457 9 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | IκBα |
| Synonyms | NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA |
| Location | Cytoplasm, Nucleus |
| Accession | P25963 |
| Clone Number | SDT-457-9 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500 | |
| ICC | 1:100 | |
| ICFCM | 1:500 |
Background
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm [PMID: 9865693]. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning [PMID: 7590248].
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4.2 ★★★★★
Based on 1382 reviews
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Product Reviews
★★★★★ 4
Not as sturdy as a regular one
Size: Mini
I was holding off writing a review about this because I wasn’t sure that it was going to hold up as well as a regular non bendable Chuck It wand. I have found I like the way it folds up and fits into my backpack nicely and also fits into my big purse when I’m out and about with my dog. You have to make sure the orange sleeve is over the screw part in the middle of the wand before you can throw the ball otherwise it’s not going to throw. It’s going to collapse. I’m not sure how long the durability is going to last that’s my only question about this product and I don’t know how long the screws on the elbow of it are gonna hold up but for now it’s been working great and we play with it every day and I’ve not had a problem with it. It’s just not as sturdy as a full size wand
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Reviewed in the United States on September 13, 2024
★★★★★ 5
Love this version of Chuck It beyond all before
Size: Mini
I had the longer bendable Chuck It before, well several, which broke down. They finally wouldn’t’ release the ball.
Not disparaging Chuck It.
They have been my furry puppy's favorite thing ever. I am grateful.
But what I like and think is intuitive about this smaller design is 2 things:
1. I can do a more dynamic throw.
2. There are circle holes in the Chuck It Ball that come with it that I think allow for easier release and the ball can go father.
Just my two cents.
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Reviewed in the United States on January 8, 2026
★★★★★ 3
Still Good to Use in a Pinch
Size: Mini
Love the Chuck it brand. This collapsible one is not my favorite. Everytime I chuck it, the orange lock does not stay in place. Plus, in my opinion, it doesn't have the oomph for the distance like the other medium ones. Still good though
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Reviewed in the United States on January 28, 2026
★★★★★ 5
Great For Dog Park Fun -- The Ball Goes Flying
Size: 25in, Style: Sport
I love this thing. It's super well made and It enables me to chuck a ball the entire length of the dog park (I'm a 65 yr old woman with a wimpy arm). My dog is thrilled too. At first I thought it might be too heavy, but that's just not an issue, the weight is fine. For non-throwers like me someone at the dog park gave me a tip --- just look at the area you want to throw the ball. Helped my aim immensely.
The 2.5 inch chuck it ball it comes with is my dog's absolute *favorite* . . . it's her security blanket in the kennel while driving, and it's her favorite ball to chase (the only one she'll actually bring back). She loves to chew it and to squish the air out of it, which takes a little effort.
Recommend.
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Reviewed in the United States on May 25, 2025
★★★★★ 5
Great tool!
Size: 18in, Style: Sport
Ok - so I do not have a dog!!! I purchased this item for a completely different purpose! I saw someone using this to gather eggs!! I often go to my daughter and son-in-law's homestead to carry out the chores when they need to be out of town! Well, I am a bit on the short side (4'11") and some of the hens KNOW that a short person is going to be gathering eggs!!! I simply could not reach all of the eggs in a couple of the nesting boxes! So, after seeing someone else use this ball launcher as an egg retriever, I bought one! I am now able to reach ALL of the eggs - one at a time with no breakage! It was a game changer for me.
I am sure that it works equally well for dog play!!!
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Reviewed in the United States on November 15, 2024
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