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Description
p21 Waf1/Cip1 Mouse mAb (469-2)Product Specification Host Mouse Antigen p21 Waf1 Cip1 Synonyms WAFT, Cyclin dependent kinase inhibitor 1, CDK interacting protein 1, MDA 6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1 Immunogen Synthetic Peptide Location Nucleus Accession P38936 Clone Number 469 2 Antibody Type Mouse mAb Isotype IgG2a Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Mouse |
| Antigen | p21 Waf1/Cip1 |
| Synonyms | WAFT, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P38936 |
| Clone Number | 469-2 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500 | |
| ICC | 1:500 | |
| ICFCM | 1:50 |
Background
p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes [PMID: 8259214], though is primarily associated with inhibition of CDK2 [PMID: 8259214, PMID: 8242751]. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest [PMID: 9822382]. his protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.
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