SKU: 92117622711

LIGANDROL (LGD-4033) Solution, 300mg (10mg/mL)

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Description

LIGANDROL (LGD-4033) Solution, 300mg (10mg/mL)LIGANDROL (LGD 4033) LGD 4033, also known as Ligandrol, VK5211, or Anabolicum, is a Selective Androgen Receptor Modulator (SARM). Various animal studies have demonstrated that it increases anabolic activity in muscles. It has also shown positive effects on bone density in male rats suffering from hypogonadism and has been successful in treating female postmenopausal rats experiencing osteoporosis. LGD 4033: Effects on Bones and Muscles Research

LIGANDROL (LGD-4033)

LGD 4033, also known as Ligandrol, VK5211, or Anabolicum, is a Selective Androgen Receptor Modulator (SARM). Various animal studies have demonstrated that it increases anabolic activity in muscles. It has also shown positive effects on bone density in male rats suffering from hypogonadism and has been successful in treating female postmenopausal rats experiencing osteoporosis.

LGD 4033: Effects on Bones and Muscles

Research presented at the 62nd Annual Meeting of the Gerontology Society of America revealed that the use of LGD 4033 in animals increased both resistance to fractures and bone mineral density after 12 weeks. These effects were observed in porous bone at a dose of 0.3 mg/kg per day and in cortical bone at a dose of 0.03 mg/kg per day (source).

In both hypogonadal and normal rats, LGD 4033 increased skeletal muscle mass and the diameter of muscle fibers. This correlated with an increased contractile strength of the muscles, indicating improved muscle power.

In an intriguing study conducted by Roche et al., 3-month-old Sprague-Dawley rats underwent ovariectomy and were treated with LGD 4033 for 5 weeks. Rats in the experimental groups received doses ranging from 0.04 to 4 mg/kg of body weight per day. Subsequent analyses were performed on fiber size, capillary density, and various enzyme levels. Additionally, the weights of the uterus, gastrocnemius, and soleus muscles were measured before and after treatment (source).

In analyzing the effects of LGD 4033, researchers also took samples from the quadriceps femoris muscle to measure changes in intramuscular fat content. Treatment with LGD 4033 resulted in an increased capillary density and higher enzymatic activity of both citrate synthase in the gastrocnemius muscle and lactate dehydrogenase in the longissimus muscle (source).

Concentration
10mg/ml.

Half Life
24 – 36 hours.

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or domestic use. Please familiarize yourself with our DISCLAIMER before ordering.

Data Sheet

LIGANDROL (LGD-4033) Solution, 300mg (10mg/mL)

Application Selective Androgen Receptor Modulator
CAS 1165910-22-4
Molar Mass 338.25 g/mol
Chemical Formula C14H12F6N2O
IUPAC Name 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Synonyms LG4, LG-4, 1165910-22-4, UNII-1EJT54415A, 4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile, 1EJT54415A, 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile, 4-{(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl}-2-(trifluoromethyl)benzonitrile, SCHEMBL221159, DTXSID10657620, EX-A729, PUBCHEM_44137686, BCP07128, s8822, ZINC95830588, AKOS022173564, CS-4667, DB13934, AC-30218, AK141891, HY-13981, AX8259791, A14346, J-690039, Q21098841, 4-[(2R)-2-[(1R)-2,2,2-TRIFLUORO-1-HYDROXYETHYL]PYRROLIDIN-1-YL]-2-(TRIFLUOROMETHYL)BENZONITRILE, Benzonitrile, 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)-
Storage Room temperature
Solubility Soluble in Ethanol, PEG400, PG, Glycerin
Organoleptic Profile Slightly Occluded Clear Liquid
Physical Form Solution in PEG400
Specification 10mg/mL ±5%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
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SKU: 92117622711

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J
Just ask Babs
Lexington, US
★★★★★ 3
Just another reason to bark.
Color: Blue
I was so excited to come across this Interactive Dog Toy from Mewzoo, figuring that it would be a great way to give our dog some inside exercise during the rainy season that we have in this neck of the woods. It arrives with a charger, instructions and two ropes that can be tied to it, and it took about 2 hours to get it fully charged. In order to get it moving, one needs to unscrew the blue plastic piece and that gives access to the control inside of it. It has three speeds, but the faster speeds only seem to lessen the time intervals for when it moves, they don't make it move any faster or further. This is kind of a bummer, because it really does not move very far, it mostly just stays within a foot or two of where it started. So not much exercise potential here, unless you consider barking exercise. Barking is one thing we do not need more of in this household, so this toy is a bit of a flop for us. I imagined that our boy might run circles around it and get a bit more hyper, maybe even grab it by the rope and carry it around for a bit. In the beginning I think he was fearful because he just barked at it of it, and then he decided it was time to eat. As you can see in the video, after only a few minutes with it, it looks like he's decided it's just a nuisance, lol. The concept is good, and the toy itself is reasonably constructed to withstand some playtime. I just think it needs to have more movement and skitter around better to cover more distance. Then again at the whopping price of $10.99, i really can't complain.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 21, 2026
S
Verified Purchase
Sandra
Whiting, US
★★★★★ 1
My dog was scared
Color: Blue
It scared my dog, he didn’t like it at all.
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Reviewed in the United States on June 8, 2026
N
Nate
Omaha, US
★★★★★ 5
Good interactive toy that keeps even my poodle mix busy
Color: Blue
We have a poodle mix that easily gets bored with most toys, including the other interactive bouncy balls. This toy seems to keep him busy though and so far he has not destroyed it or grown bored of it. The only problem we have is keeping it charged because he seems to wear it out but it is not a problem to recharge it with the USB cable that is included. It is a little tricky screwing the toy back together after charging the battery but I am getting the hang of it. Once it is set to one of the play modes the ropes on top (that you need to put on) will start spinning back and forth and the toy gyrates around seeming like it is alive to our dog. The loves playing with it in all of the modes but I think he likes that faster modes better. It comes with an extra rope which was good because our raptor dog already ripped the first one apart. The price on this toy is relatively low compared to tother toys to I highly recommend this for anyone that has a dog who is bored with the typical play toys.
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Reviewed in the United States on February 22, 2026
S
Verified Purchase
S. Weir
Port Orchard, US
★★★★★ 5
Great entertainment for kittens too!
Color: Blue
My kittens love this toy and play with it more than my dog. I bought it on sale. I am impressed with the quality, ease of use, and I rarely need to charge it.
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Reviewed in the United States on June 10, 2026
S
Verified Purchase
Sue Elliott
Chelsea, US
★★★★★ 1
Do not buy… false advertising does not move!!
Color: Red
Terrible!!! No directions & no movement at all!!! Button?? Push…. Sure there is no button No way to charge… Scam
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Reviewed in the United States on May 29, 2026

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