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Description
GW-0742 Powder, 1grGW 0742 GW 0742 functions as a dual PPAR agonist and antagonist, with its specific action depending on the dosage administered. Additionally, it demonstrates low level activity on various nuclear receptors. It has been identified as an antagonist for both androgen receptors and Vitamin D Receptors (VDR). Computational (in silico) modeling indicates that GW 0742 may also exert influence on thyroid hormone receptors. Multiple studies suggest that GW
GW-0742
GW-0742 functions as a dual PPAR-β agonist and antagonist, with its specific action depending on the dosage administered. Additionally, it demonstrates low-level activity on various nuclear receptors.
It has been identified as an antagonist for both androgen receptors and Vitamin D Receptors (VDR). Computational (in silico) modeling indicates that GW-0742 may also exert influence on thyroid hormone receptors.
Multiple studies suggest that GW-0742 can ameliorate experimentally-induced pancreatitis in mice. It has further been shown to mitigate hypertension in diet-induced obese mice. Currently, it is under investigation as a prospective antidiabetic agent and has demonstrated anti-inflammatory effects.
Half-Life
24 hours
Disclaimer
This substance is exclusively available for laboratory research purposes. Sale terms and conditions apply. It is not intended for human consumption, or for use in medical, veterinary, or household applications. Please consult our disclaimer prior to making a purchase.
Included is a precision pipette marked per 0.2 ml!
Shake well before use.
Data sheet
GW-0742 – Solution, 600mg (20mg/mL)
| Application | Potent PPARβ and PPARδ agonist |
| CAS | 317318-84-6 |
| Molar Mass | 471.5 g/mol |
| Chemical Formula | C21H17F4NO3S2 |
| IUPAC Name | 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid |
| Synonyms | GW0742, 317318-84-6, GW 0742, GW-0742, GW0742X, GW610742, GW-0742X, CHEMBL38508, CHEBI:79991, {4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]-4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic Acid, SR-05000000447, 3tkm, GW 0742X, GWdelta 0742, GW 610742, GW-610742, DSSTox_CID_20760, DSSTox_RID_79591, DSSTox_GSID_40760, MLS006011159 |
| Storage | Store at room temperature, tightly sealed, away from heat, light and moisture. |
| Solubility | Soluble in DMSO, PEG 400 |
| Organoleptic Profile | Clear liquid |
| Physical Form | Powder |
| Specification | |
| Terms | This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering. |
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