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Description
mrp8 vesicle kitHuman MRP8 Vesikel Kit Inside Out Membranvesikel fr Steroidsulfat , Gallensure und Nukleosidanalogon Transportstudien Das Human MRP8 Vesikel Kit (HEK293 abgeleitet) liefert gebrauchsfertige Inside Out Membranvesikel fr ATP abhngige Transportstudien von MRP8 (ABCC11). MRP8 wird in Gehirn, Brustdrse, Leber und Hoden exprimiert und transportiert ein charakteristisches Substratprofil einschlielich Steroidsulfate, Gallensuren, cAMP und
Human MRP8 Vesikel-Kit – Inside-Out-Membranvesikel für Steroidsulfat-, Gallensäure- und Nukleosidanalogon-Transportstudien
Das Human MRP8 Vesikel-Kit (HEK293-abgeleitet) liefert gebrauchsfertige Inside-Out-Membranvesikel für ATP-abhängige Transportstudien von MRP8 (ABCC11). MRP8 wird in Gehirn, Brustdrüse, Leber und Hoden exprimiert und transportiert ein charakteristisches Substratprofil einschließlich Steroidsulfate, Gallensäuren, cAMP und Nukleosidmonophosphat-Analoga. Es ist von besonderer Relevanz in Brustkrebsforschung-DDI-Studien, ZNS-Arzneimittelentwicklung und metabolischem Profiling von Steroidkonjugaten.
Transporterprofil
MRP8 (ABCC11) transportiert Steroidsulfate (DHEAS, E1S), monoanionische Gallensäuren, cAMP, Glutathionkonjugate und Nukleosidmonophosphat-Analoga. Seine Expression in der Brustdrüse ist in der Brustkrebsforschung von Interesse, und seine ZNS-Expression ist für die Gehirn-Arzneimittelverteilung relevant. Maus- und Ratten-MRP8-Isoformen sind auf Anfrage erhältlich. Wichtige Substrate: DHEAS (Dehydroepiandrosteron-3-Sulfat), E1S (Estron-3-Sulfat), LTC₄, cAMP.
Technische Spezifikationen
| Parameter | Spezifikation |
|---|---|
| Transporter | Human MRP8 (Multidrug Resistance-Associated Protein 8) (ABCC11) |
| Expressionssystem | HEK293 (transiente Überexpression) |
| Vesikeltyp | Inside-Out-Membranvesikel |
| Reaktionen pro Kit | 100 |
| ATP/AMP-Transportverhältnis | >5 |
| Detektionskompatibilität | Radiolabel, LC-MS/MS |
| Lagerung | −80 °C (Lieferung auf Trockeneis) |
| Kit-Inhalt | Vesikel, ATP, AMP, Reaktionspuffer, Waschpuffer, CoA |
| Hersteller | Cell4Pharma (Netherlands) |
| Distributor DACH | SeamlessBio GmbH, Passau |
Anwendungsgebiete
| Anwendung | Beschreibung |
|---|---|
| Steroidsulfat-Efflux-Studien | Charakterisierung des Transports von DHEAS, Estronsulfat und anderen Steroidsulfatkonjugaten — relevant für das Verständnis der Hormon-Arzneimittelverteilung und des Metaboliten-Efflux in Brust- und Lebergeweben. |
| Brustkrebs / Brustgewebe-DDI | MRP8 in Brustgewebe vermittelt den Efflux von Steroidhormonen und bestimmten Krebsmitteln. Relevant für die Brustkrebsarzneimittelentwicklung und das Verständnis hormoneller Arzneimittelinteraktionen. |
| ZNS- und Gallensäuretransport | ZNS-Expression von MRP8 kann die Gehirnexposition von Steroidsulfatkonjugaten einschränken. Die Gallensäure-Transportkapazität macht MRP8 in hepatischen Cholestase-Studien neben BSEP und MRP2 relevant. |
Assay-Prinzip
Inside-Out-Membranvesikel präsentieren die zytoplasmatische Seite des Transporters dem Assaypuffer und ermöglichen so ATP-abhängige Substrataufnahme in das Vesikelinnere. Vesikel mit Testverbindung und Probesubstrat in Gegenwart von ATP (Transport) oder AMP (Hintergrundkontrolle) inkubieren. Reaktion mit kaltem Waschpuffer stoppen, Vesikel durch Filtration trennen und akkumuliertes Substrat per LC-MS/MS, Radiolabel oder Fluoreszenz quantifizieren. Das ATP/AMP-Verhältnis bestimmt das Assay-Fenster für die zuverlässige IC₅₀-Bestimmung.
Komplettes Cell4Pharma Kit-Portfolio bei SeamlessBio
Alle ABC-Transporter-Vesikel-Kits aus einer europäischen Quelle — schnelle Kühlkettenlieferung, garantierte ATP/AMP-Verhältnisse, vollständige Dokumentation.
| Kit | Transporter | Gen | ATP/AMP-Verhältnis |
|---|---|---|---|
| Human BCRP Vesicle Kit | BCRP | ABCG2 | >10 |
| Human BSEP Vesicle Kit | BSEP | ABCB11 | >10 |
| Human MRP1 Vesicle Kit | MRP1 | ABCC1 | >5 |
| Human MRP2 Vesicle Kit | MRP2 | ABCC2 | >20 |
| Human MRP3 Vesicle Kit | MRP3 | ABCC3 | >5 |
| Human MRP4 Vesicle Kit | MRP4 | ABCC4 | >5 |
| Human MRP5 Vesicle Kit | MRP5 | ABCC5 | >5 |
| Human MRP8 Vesicle Kit | MRP8 | ABCC11 | >5 |
| Human Pgp Vesicle Kit | P-gp / MDR1 | ABCB1 | >5 |
| Human Pgp + FluoPgp Kit | P-gp / MDR1 | ABCB1 | >5 |
| Human Control Vesicle Kit | — | HEK293 empty vector | — |
Qualität & Regulatorische Konformität
- Produziert von Cell4Pharma — Spezialhersteller für ABC-Transporter-Vesikelsysteme
- Garantiertes ATP/AMP-Transportverhältnis >5 pro Charge
- Große, einheitliche Chargen — maximale Lot-zu-Lot-Konsistenz
- Chargenspezifischer QC-Bericht + Datenblatt bei jedem Kit inklusive
- Konform mit FDA DDI Guidance (2020) und EMA DDI Guideline (2013/2022)
Warum über SeamlessBio bestellen?
| Vorteil | Beschreibung |
|---|---|
| ✅ EU-Lagerverfügbarkeit | Schnelle Kühlkettenlieferung in Deutschland, Österreich, Schweiz und der EU |
| ✅ Direktkontakt | Direkter Kontakt zum Fachberater — auf Deutsch oder Englisch |
| ✅ Vollständige Dokumentation | Datenblatt, QC-Bericht und Rechnung bei jeder Lieferung |
| ✅ Chargenreservierung | Spezifische Charge für die gesamte Projektlaufzeit reservieren |
| ✅ Komplettes Portfolio | Alle 11 Cell4Pharma Kits aus einer Quelle — BCRP, BSEP, MRP1–8, Pgp, Kontrolle |
Bestellung oder Preisanfrage: [email protected] | +49 851 37932226
Häufige Fragen
Ist MRP8 für Maus- und Ratten-Isoformen erhältlich?
Ja — Maus- und Ratten-MRP8 (ABCC11)-Isoformen sind auf Anfrage bei Cell4Pharma erhältlich. Kontakt: [email protected]
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.0 ★★★★★
Based on 22 reviews
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Product Reviews
★★★★★ 5
The best…
5120x2160! Did you read the 2160 vertical!? Yea I can’t stress that enough. Gosh I find it so frustrating there arnt more options in this space.
Here is the deal, if you have multiple monitor setup (and you should if you have a work station) you likely will have a couple of 4k monitors kicking around. Now these 4k monitors are staples, and they all have 2160 vertical. If you have 1140 vertical like almost ALL ultra wide monitors do then there will be this annoying stepping with your mouse when you go from one screen to the next. It drives me nuts that the standard for these ultra wides does this. If you don’t have the same resolution vertical from one screen to the next then you won’t have a seamless transition from one screen to the next. It’s just the facts.
This dell is one of the only curved ultra wide monitors with 2160 vertical resolution. It runs at 120 hertz which also believe it or not makes it one of the only 5120x2160 resolution monitors on the market to do that. I’m sure you can tell by my writing I have owned a lot of high quality monitors in my time and this one for me is by far the best.
I’m switching from a none curved ultra wide 32” LG that runs at 60hrtz. Needless to say this is way better, and sadly there was like this burn in that occurred on my LG that would eventually go away but stick around for the better part of a day. This ultimately put me back in the market looking for a replacement.
Point being, now I only buy dell monitors. I’ve never had issues with them , they have great color reproduction, pretty affordable (as of now), basically super reliable all around.
Obviously I’m not thrilled about the lack of options for folks that have real work to do on there pcs. All this gamer b.s. in the marketplace, it’s all junk as far as I’m concerned. So if you actually have productive things to do on your pc then you can’t do much better then this monitor, I highly recommend. My only gripe is I wanted a smaller version of this maybe a 32” or 36”, it simply doesn’t exist on the market as of now. However, this works for me, the curved surface buys me back a little desk relestate, and it’s something I really missed with my previous monitor.
Side note, I definitely recommend monitor arms for all your monitors. I bought one for the larger center monitor (this one) and it works great. Just be sure you buy one that has a high weight capacity, ideally 44lbs or more. This monitor given its size is 42lbs I believe (although honestly it doesn’t feel nearly that heavy). So just be prepared for that. Hope this is helpful, and I hope the manufacturers wake up one day and realize this screen resolution isn’t a nice to have, it’s a must for a lot of people.
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Reviewed in the United States on December 2, 2024
★★★★★ 5
Perfect “Command Center” Monitor for Mac Studio – Worth the Money
Title: Perfect “Command Center” Monitor for Mac Studio – Worth the Money
I’m using this Dell U4025QW with a Mac Studio M2 Max, and it’s exactly what I wanted: a huge, sharp, curved workspace that also handles games really well. The 40” 5K2K screen lets me keep Docs, email, browser, and gradebook all open at once without feeling cramped, and the curve makes it comfortable to use for long stretches. Text is clear, colors look great out of the box, and bumping it up to 120 Hz makes macOS feel noticeably smoother.
The Thunderbolt/USB-C hub is a big bonus – one cable to the Mac, and everything else (keyboard, mouse, etc.) can live on the back of the monitor, so the desk stays clean. It’s not cheap, but if you live in documents all day and also want your games to look and run smoothly, this is a fantastic “do it all” monitor and I have zero regrets about the purchase.
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Reviewed in the United States on December 29, 2025
★★★★★ 5
The best business monitor
I have used many of the monitors in the Dell UltraSharp line and thought that my previous monitor, the U4021QW was the apex of Business monitors. The U4025QW improves on it in small but meaningful ways. Looking at the monitor, you can't visually tell the difference at first glance.
To me the ultra-wide curved monitor format is preferrable to dual monitors. The 5120 x 2160 / 21:9 screen ratio gives the business user more vertical space while not sacrificing the horizontal space. Many ultrawide monitors give you the width of 5120 but stick you with 1440 vertically. That resolution always felt cramped to me.
This connectivity on this monitor far exceeds its predecessor. It is upgraded from Thunderbolt 3 to Thunderbolt 4, adds 2 usb-c ports and one USB-A, giving a total of 5 USB-A and 5 USB-C. This allowed me to replace my old desktop dock and go with a direct connection to the monitor for everything.
When reading about the monitor, I thought the drop-down ports were a bit gimmicky, but it is a big improvement over the location on the previous model. This is very accessible and helps with wireless devices whose signal degrades by being placed behind the monitor.
The monitor is pricey, but I think it is worth it if you are on your computer all day every day. As on co-worker once said, the monitor is the part of the computer that we use 100% of the time we interact with it.
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Reviewed in the United States on December 13, 2025
★★★★★ 5
Extremely sturdy
Color: Black-Mount
I purchased this heavy-duty dual gaming monitor arm holder as a birthday gift for my husband to mount his curved gaming screens, and it completely transformed his setup. It feels extremely sturdy and well-built, easily supporting both monitors without any wobble or instability.
The adjustability is excellent. He can tilt, swivel, and reposition each screen with ease, which makes it perfect for both gaming and everyday computer use. It also helps clear up a lot of desk space, giving his setup a much cleaner and more organized look.
Installation was straightforward, and the mounting hardware felt solid and secure. Once everything was set up, the arms moved smoothly but stayed firmly in place when adjusted.
He absolutely loved it and immediately noticed how much more comfortable and immersive his gaming experience became. Overall, this is a high-quality, durable monitor mount that made a perfect upgrade for his gaming station and a great birthday gift.
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Reviewed in the United States on April 23, 2026
★★★★★ 5
The Product is Great - The Customer Service is Even Better
Color: Black-Mount
I want to preface by saying I have never written a review for a product on Amazon. Having said that I felt compelled to review this particular product after an incredibly positive interaction I had with AVLT.
I purchased this set of monitor arms due to the fact that my desk is relatively small, as is the space I have to work with while at my computer. I currently have two monitors, a 34" Samsung 2K monitor for gaming, and a 32" Samsung 1080p monitor. After purchasing this product and assembling it, I realized my 2nd monitor (32") was a few years too old and the bracket adapter for the monitor arm didn't fit. That was fine, as at least I had some extra space to work with until I got myself a new monitor to use with the other monitor arm. Fast forward several months and I finally had the monitor I needed - only to find out that I had lost or misplaced the additional bracket. So now I had 3 monitors and even less space to work with. After a lengthy search for a sufficient replacement part, I finally reached out to AVLT in desperation regarding this missing bracket. My query was answered by an employee named "George" the very same day, and within 48 hours I was able to secure the replacement bracket which is currently en route to my house from Taiwan. Alongside the headache of not being able to properly mount the monitors I had on hand, I start working from home this coming week, and my wife is currently 33 weeks pregnant. Needless to say, the ease with which I was able to negotiate this minor, yet irritating problem I was dealing with has helped me more than any Amazon review can ever repay. The help I received from George was simply outstanding, and I hope he receives the recognition he deserves from the company he works for. Sometimes even little things like a quick response can help people more than you realize. Thank you, George and AVLT!
Oh, and the monitor arms are great. They're sturdy (metal not plastic), firmly clamp to my desk, and are easily adjustable. As stated in some previous reviews, there is a bit of clearance needed behind your desk in order for these monitor arms to move about, but that's a minor inconvenience at worst. I recommend them, and the fact that the company is there to help should anything go awry is extremely helpful in a world where the emphasis on this seems to be fading away. If I ever need a product similar to this one, or know anyone who does, I will recommend AVLT products specifically based on the customer service I received (the product is awesome too).
Thanks again, George!
- Joel
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 30, 2023
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